研究员，博士生导师，中国科学院人才项目入选者（2019）、湖南省杰青获得者（2022）、饲料产业技术创新战略联盟草食动物健康生产专业委员会委员，湖南省奶业协会理事。2012-2017年先后在加拿大农业部莱斯布里奇研究中心（Lethbridge Research Centre, AAFC）和加拿大阿尔塔大学(University of Alberta)从事博士后研究。长期从事草食动物营养生理与农牧复合研究与示范工作，近年来主持国家自然科学基金项目3项、中国科学院科技服务网络STS重点项目、A类战略先导子课题、内蒙古揭榜挂帅课题等重大科研项目等10余项。担任Annals of Applied Biology编委，Animal Nutrition青年编委，Frontiers in Veterinary Science、Frontiers in Microbiology特邀副主编，在Communication Biology、Animal Nutrition等期刊发表第一或通讯作者论文60余篇。
课题组围绕反刍动物全生命周期关键阶段的产能性状形成分子机制、靶向调控技术、模式与产品应用等方面开展了大量工作。主要包括：1）在新生阶段，首次明确初乳免疫球蛋白G吸收效率下降受网格蛋白介导胞吞途径以及巨胞饮途径基因表达影响，构建羔羊初乳饲喂调控方案，多胎羔羊存活率提升50%；绘制3-8月龄生长羔羊全消化道多器官转录变化图谱，解析断奶前羔羊日增重快的分子机制及其对机体长期影响，解码生长羔羊宿主和消化道微生物ATP生成的作用途径，并构建肉羊低蛋白日粮（粗蛋白：14.57%降至12.46%）、大宗本地杂粕代替豆粕（每吨饲料降低200元）、高比例精料（60%为宜）育肥营养调控技术。2）在先导呼伦贝尔示范区创建“母子一体化营养、早期断奶、短期育肥”的二年三产模式与全生命周期日粮产品，相较传统一年一产模式每只基础母羊年增收200元，经济效益显著，技术应用助推大型国营农场“由农转牧，农牧结合”转型升级目标的实现。
欢迎对相关研究内容感兴趣的硕士生、博士生和博士后加入我们！
项目主持：“本土畜种高效养殖示范和产品品牌打造”，2020.11-2025.10，A类先导科技专项子课题；
项目主持：“优质草原羊全产业链高效生产体系构建与示范”，2020.01-2021.06，中国科学院STS重点项目；
项目主持：“新生羔羊被动免疫功能形成及调控机制研究”，2018.01-2021.12，国家自然科学基金面上项目；
项目主持：“新生羔羊分泌型IgA驱动肠道微生物定植机理及初乳调控”，2021.01-2024.12，国家自然科学基金面上项目；
课题主持：“南方非常规饲草料资源利用和生鲜乳品质调控技术研发与应用示范”，2019.01-2020.06，中国科学院STS项目课题；
1) Chao Yang, Yan Cheng, Fan Hu, Hui Mi, Tianxi Zhang, Leluo Guan, Michael Steele, Zhixiong He* and Zhiliang Tan*. Multi-omics analysis provides new insights into the molecular mechanisms underlying colostral immunoglobulin G absorption in the gut of neonatal goat kids. Animal Nutrition. 2025, In press.
2) Kefyalew Gebeyew, Hui Mi, Ruiping Du, Min Gao, Diriba Diba, Shaoxun Tang, Zhixiong He*, Zhiliang Tan. Wheat straw and alfalfa hay alone or combined in a high-concentrate diet alters microbial-host interaction in the rumen of lambs. Animal Nutrition. 2025, 20: 444-457.
3) Fan Hu, Yan Cheng, Bing Fan, Wei Li, Bingsen Ye, Zhiwu Wu, Zhiliang Tan, Zhixiong He*. Ruminal microbial metagenomes and host transcriptomes shed light on individual variability in the growth rate of lambs before weaning: the regulated mechanism and potential long-term effect on the host. mSystem 2024. 9: e00873-24.
4) Kefyalew Gebeyew, Hui Mi, Yong Liu, Yongbin Liu*, Biao Wang, Teka Feyera, Tan Zhiliang, Zhixiong He*. Differential immunological responses in lamb rumen and colon to alfalfa hay and wheat straw in a concentrate-rich diet: insights into microbe-host interactions. mSystems. 2024. 9: e00483-24.
5) Yan Cheng, Tianxi Zhang, Chao Yang, Kefyalew Gebeyew, ChengyuYe, Xinxin Zhou, Tianqi Zhang, Ganyi Feng, Rui Li. Zhixigng He*, OrenParnas*, Zhiliang Tan*. Low Expression of CCKBR in the Acinar Cells is Associated with Insufficient Starch Hydrolysis in Ruminants. Communications Biology.2024, 7:1686.
6) Zhang T, Ren Y, Yang C, Gebeyew K, Gao M, He Z* and Tan Z (2023) An integrated transcriptome and microbial community analysis reveals potential mechanisms for increased immune responses when replacing silybum marianum meal with soybean meal in growing lambs. Front. Microbiol. 14:1093129.
7) Hui Mi, Fan Hu, Kefyalew Gebeyew, Yan Cheng, Ruiping Du, Min Gao, Zhixiong He* and Zhiliang Tan. Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs. BMC Genomics (2023) 24:364.
8) C. Yang, T.X Zhang, Q.H Tian, Y Cheng, K Gebeyew, G.W. Liu, Z.L. Tan, Z.X. He*. Supplementing mannan oligosaccharide reduces the passive transfer of IgG and improves antioxidative capacity, immunity and intestinal microbiota in neonatal goats. Frontiers in Microbiology, 2022. 12:795081.
9) Z.X. He, CS Zhou, M Wang, G Yang, R.Z Zhong, JZ Jiao, Shaoxun Tang, Zhiliang Tan*. Developing Strategies of Functional Milk and Meat Products from Herbivorous Animal Husbandry. Bulletin of Chinese Academy of Sciences. 2021, 36, 685-691.
10) Gebeyew K, Yang C, He ZX*, Tan ZL. Low-protein diets supplemented with methionine and lysine alter the gut microbiota composition and improve the immune status of growing lambs. Applied Microbiology and Biotechnology, 2021, 105: 8393–8410.
11) Gebeyew K, Chen K, Anley TW, Azad AK, He JH, Jiang WM, Song W, Tan ZL, He ZX*. Dietary amylose/amylopectin ratio modulates cecal microbiota and metabolite in weaned goats. Frontiers in Nutrition, 2021, 8: 774766.
12) C. Yang, Y. Cheng, X.L. Li, H.Q. Li, Q.X. Yan, Z.X. He*, Z.L. Tan, Effects of dietary Macleaya cordata extract inclusion on transcriptomes and inflammatory response in the lower gut of early weaned goats. Animal Feed Science and Technology, 272 (2021) 114792.
13) 常馨丹, 胡帆, 伍志武, 叶炳森, 刘铁海, 林杰, 贺志雄*, 谭支良. 日粮添加高比例过瘤胃脂肪对生长肉用绵羊采食行为的影响. 畜牧兽医学报[J], 2024,55(03),1077-1084.
14) 米慧, 彭灿*, 贺志雄*, 谭支良. 基于流式细胞术分选绵羊分泌型IgA包裹的消化道细菌. 畜牧兽医学报[J] , 2023, 54(7). 2924-2931.
15) 贺志雄, 胡兆民, 王竑晟, 焦金真, 韩雪峰, 刘勇, 汤少勋, 周传社, 王敏, 谭支良. 持续推进反刍家畜全生命周期营养工程的创新与发展. 中国科学院院刊[J], 2023, 38(7): 1067-1076.
16) 贺志雄, 周传社, 王敏, 杨果, 钟荣珍, 焦金真, 汤少勋, 谭支良*. 草食畜牧业乳肉功能性产品发展的战略思考[J]. 中国科学院院刊, 2021, 36(6): 685-691.
17) 杨超, 田全华, 阳利, 程艳, 贺志雄*, 谭支良. 初乳饲喂对新生羔羊肠道渗透性及粘附微生物组成的影响[J]. 动物营养学报, 2021, 33(03): 1503-1512.
18) 陈凯，刘勇，冉涛，贺建华*，贺志雄*，谭支良. 高直链淀粉玉米替代普通玉米对断奶羔羊生长性能、营养物质表观消化率和血液生理生化指标的影响[J]. 动物营养学报，2021, 33(02): 965-973.
19) 陈凯，江为民，贺志雄*，贺建华*，谭支良. 玉米品种和淀粉老化处理对其红外光谱结构与体外发酵参数的影响[J]. 动物营养学报, 2021, 33(07): 3980-3993.
20) 田全华, 赵旭, 刘勇, 魏凌云*, 谭支良, 贺志雄*. 饲粮添加黄芪和葡聚糖硫酸钠盐对羔羊后肠道发酵和微生物组成的影响[J]. 中国畜牧兽医, 2021, 48(09): 3242-3253.
21) 程艳, 杨超, 许丽卫, 耿梅梅, 谭支良, 贺志雄*. 基于UPLC-MS/MS技术研究濒死状态下新生羔羊血清代谢物变化[J].畜牧兽医学报,2020, 51(12): 3199-3204.
22) He ZX#, Qiao J#, Yan Q, Tan Z, Wang M*, 2019. Quantitative evaluation of ruminal methane and carbon dioxide formation from formate through C-13 stable isotope analysis in a batch culture system. Animal, 2019, 13: 90-97.
23) He ZX, Ribeiro G, Beauchemin KA, McAllister TA, Yang WZ*. Inoculum source and transfer of rumen contents from bison to cattle improved in vitrogas production and feed digestibility, but not the responses to exogenous enzymes supplementation. Animal Feed Science and Technology, 2019, 248: 37-46.
24) He ZX, Qiao JY, Tan ZL, Wang M*. Carbon-13 stable isotope analysis reveals the existence but insignificance of ruminal methanogenic pathway from acetate in a batch culture system. Animal Feed Science and Technology, 2018, 246: 46-51.
25) He ZX, Fischer A, Song Y, Steele M*, Guan LL*. Genome wide transcriptome analysis provides bases on colonic mucosal immune system development affected by colostrum feeding strategies in neonatal calves. BMC Genomics, 2018, 19: 635.
26) He ZX, Ferlisi B, Eckert E, Brown HE, Aguilar A, Steele MA*. Supplementing a yeast probiotic to pre-weaning Holstein calves: feed intake, growth and fecal biomarkers of gut health. Animal Feed Science and Technology, 2017, 226: 81-87.
27) He ZX, Zhao YL, McAllister TA, Yang WZ*. Effect of in vitro techniques and exogenous feed enzymes on feed digestion. Animal Feed Science and Technology, 2016, 213, 148-152.
28) He ZX, Sun ZH, Beauchemin KA, Yang WZ, Tang SX, Zhou CS, Han XF, Wang M, Kang JH, Tan ZL*. Effect of protein or energy restriction during late gestation on hormonal and metabolic status in pregnant goats and postnatal male offspring, Animal, 2015, 9:1843-1851.
29) He ZX, He ML, Zhao YL, Xu L, Walker ND, Beauchemin KA, Yang WZ*. Effect of wheat dried distillers grains and enzyme supplementation on growth rates, feed conversion ratio and beef fatty acid profile in feedlot steers, Animal, 2015, 9:1740-1746.
30) He ZX, Walker ND, McAllister TA, Yang WZ*. Effect of wheat dried distillers grains with solubles and fibrolytic enzymes on ruminal fermentation, digestibility, growth performance, and feeding behavior of beef cattle, Journal of Animal Science, 2015, 93:1218-1228.
31) He ZX, Sun ZH, Yang WZ, Beauchemin KA, Tang SX, Zhou CS, Han XF, Wang M, Kang JH, Tan ZL* Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats, Journal of Animal Science, 2014, 92:4856-4864.
32) He ZX, He ML, Walker ND, McAllister TA, Yang WZ*. Using a fibrolytic enzyme in barley-based diets containing wheat dried distillers grains with solubles: ruminal fermentation, digestibility, and growth performance of feedlot steers. Journal of Animal Science, 2014, 92:3978-3987.
33) He ZX, Wu DQ, Sun ZH, Tan ZL*, Qiao JY, Ran T, Tang SX, Zhou CS, Han XF, Wang M, Kang JH, Beauchemin KA. Protein or energy restriction during late gestation alters fetal growth and visceral organ mass: An evidence of intrauterine programming in goats. Animal Reproduction Science, 2013. 137:177-182.
34) He ZX, Sun ZH, Tan ZL*, Tang SX, Zhou CS, Han XF, Wang M, Wu DQ, Kang JH, Beauchemin KA. Effects of maternal protein or energy restriction during late gestation on antioxidation status of plasma and immune tissues in postnatal goats. Journal of Animal Science, 2012. 90:4319-4326.
35) He ZX, Tan ZL*, Sun ZH, Beauchemin K, Tang SX, Zhou CS, Han XF, Wang M, Wu DQ. Unchanged interleukin-6 level of protein and energy restricted goats during late gestation: the role of elevated blood nitric oxide. Journal of Endocrinology, 2012. 213:59-65.